Comparative Genomics and Understanding of Microbial Biology
نویسندگان
چکیده
منابع مشابه
Comparative genomics and understanding of microbial biology.
The sequences of close to 30 microbial genomes have been completed during the past 5 years, and the sequences of more than 100 genomes should be completed in the next 2 to 4 years. Soon, completed microbial genome sequences will represent a collection of >200,000 predicted coding sequences. While analysis of a single genome provides tremendous biological insights on any given organism, comparat...
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We are interested in quantifying the contribution of gene acquisition, loss, expansion and rearrangements to the evolution of microbial genomes. Here, we discuss factors influencing microbial genome divergence based on pair-wise genome comparisons of closely related strains and species with different lifestyles. A particular focus is on intracellular pathogens and symbionts of the genera Ricket...
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Title of Dissertation: COMPARATIVE AND COMPUTATIONAL METHODS FOR MICROBIAL GENOMICS Derrick Edward Wood, Doctor of Philosophy, 2014 Directed by: Professor Steven L. Salzberg Department of Computer Science Through the study of genomic sequences, researchers are able to learn much about the workings of life. As sequencing technology has improved over the past decade, the number of genomes that ha...
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Transmembrane chemoreceptors in Escherichia coli utilize ligand-binding domains for detecting various external signals. The structure of this domain in the E. coli aspartate receptor, Tar, is known and its signal transduction mechanism is under investigation. Current domain models for this important sensory module are inaccurate and therefore cannot reveal the distribution of this domain within...
متن کاملPrimate comparative genomics: lemur biology and evolution.
Comparative genome sequencing projects are providing insight into aspects of genome biology that raise new questions and challenge existing paradigms. Placement in the phylogenetic tree can often be a major determinant of which organism to choose for study. Lemurs hold a key position at the base of the primate evolutionary tree and will be highly informative for the genomics community by offeri...
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ژورنال
عنوان ژورنال: Emerging Infectious Diseases
سال: 2000
ISSN: 1080-6040
DOI: 10.3201/eid0605.000510